APC-conjugated CD80 Antibody (16-10A1)
(Synonyms: CD80,CD80-APC,16-10A1)APC-conjugated CD80 Antibody (16-10A1) is an Armenian Hamster-derived and APC conjugated monoclonal antibody, targeting to CD80.
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Host:
Armenian Hamster
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Isotype:
Armenian Hamster IgG
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Application:
FC
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Reactivity :
Mouse
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
APC
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
|
|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
APC-conjugated CD80 Antibody (16-10A1) is an Armenian Hamster-derived and APC conjugated monoclonal antibody, targeting to CD80.
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Host Armenian Hamster
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Clonality Monoclonal
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Species ReactivityMouse
APC
Unmodified
Armenian Hamster IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD28/CD80 is a co-stimulatory molecule belonging to the immunoglobulin superfamily that plays a crucial role in T-lymphocyte activation. CD80 interacts with the CD28 receptor-constitutively expressed on the surface of T cells-to serve as a primary co-stimulatory signal that enhances MHC/TCR signaling in naive T cells. This triggers the activation of various signaling pathways, such as NF-κB or MAPK, ultimately leading to the production of multiple cytokines. Furthermore, the CD28/CD80 co-stimulatory signal promotes T-cell glucose metabolism and ATP synthesis by activating the PI3K/Akt signaling pathway. CD80 also acts as a regulator of the PD-L1/PDCD1 interaction, limiting the excessive activation of PD-L1 and its inhibitory effects during immune responses. Expressed on the surface of B cells, CD80 plays a pivotal regulatory role in the interactions between B cells and T cells during both early and late germinal center reactions.
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Synonyms
CD80,CD80-APC,16-10A1
Documentation
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