APOBR Antibody (YA8645)(PBS only)

Cat. No.: HY-P88961A: Data Sheet User Guide for Antibodies
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APOBR Antibody (YA8645) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to APOBR.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

APOBR Antibody (YA8645) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to APOBR.

Host

Mouse

Molecular Weight

Predicted band size: 114.7 kDa

Species Reactivity

Human

SwissProt ID

Q0VD83

Immunogen

Human recombinant protein fragment corresponding to amino acids 780-1088 of human APOBR produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages

Subcellular Localization：Cell membrane

Expression：
Tissue_Specificity: Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells
Induction: Suppressed significantly by PPARA and PPARG in THP-1 and blood-borne monocyte-macrophages. Decreased after pitavastatin treatment in peripheral blood macrophages and remnant lipoprotein (RLP)-induced foam cell formation

Isoforms & Post-Translational Modification：Q0VD83 has three isomers: Q0VD83-4: 115634 Da (predicted); Q0VD83-2: 66335 Da (predicted); Q0VD83-3: 113801 Da (predicted).
There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R)

Subunit：Homodimer

Synonyms

APOB48R; APOB100R

Documentation

User Guide for Antibodies (1077 KB)