ARHGEF18 Antibody (YA7855)
(Synonyms: P114-RhoGEF)ARHGEF18 Antibody (YA7855) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ARHGEF18.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
ARHGEF18 Antibody (YA7855) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ARHGEF18.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 130.6 kDa
Human recombinant protein fragment corresponding to amino acids 118-215 of human ARHGEF18 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ARHGEF18 acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells[1].
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Subcellular Localization
Cytoplasm,Cytoplasm, cytoskeleton,Cell membrane,Apical cell membrane
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Expression
Tissue_Specificity: Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils (PubMed:29601110). Isoform 2: Expressed in eosinophils (PubMed:29601110). Isoform 3: Expressed in eosinophils (PubMed:29601110). Isoform 4: Not detected in eosinophils (PubMed:29601110) -
Isoforms & Post-Translational Modification
Q6ZSZ5 has 5 isomers: Q6ZSZ5-4: 151642 Da (predicted); Q6ZSZ5-5: 151600 Da (predicted); Q6ZSZ5-6: 149764 Da (predicted); Q6ZSZ5-2: 114077 Da (predicted); Q6ZSZ5-1: 130813 Da (predicted).
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Subunit
Interacts with SEPT9; the interaction may inhibit GEF activity (PubMed:15558029)
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SwissProt ID
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Synonyms
P114-RhoGEF
Documentation
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