ATP6V1B2 Antibody (YA7759)(PBS only)

製品番号: HY-P88075A: データシート User Guide for Antibodies
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ATP6V1B2 Antibody (YA7759) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ATP6V1B2.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

ATP6V1B2 Antibody (YA7759) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ATP6V1B2.

Host

Mouse

分子量

Predicted band size: 56.3 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P21281

Immunogen

Full length human recombinant protein of human ATP6V1B2 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

純度	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity)

Subcellular Localization：Apical cell membrane,Melanosome,Cytoplasm,Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane,Cytoplasmic vesicle, clathrin-coated vesicle membrane

Expression：
Tissue_Specificity: Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level)

Isoforms & Post-Translational Modification：P21281: 511 amino acids, molecular weight 56501 Da.

Subunit：V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (PubMed:33065002)

Synonyms

ATP6B1B2; ATP6B2; DOOD; HO57; VATB; Vma2; VPP3; ZLS2

ドキュメンテーション

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/hela-cell.html [Content Brief]