Beclin 1 Antibody (YA6368)(PBS only)
(Synonyms: Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN.)Beclin 1 Antibody (YA6368) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Beclin 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, WB, IF-Tissue, IHC-F
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-F
IHC-F: Immunohistochemistry-Frozen
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|---|---|---|---|---|
| Dilution Ratio | 1:50-200 | 1:100-1000 | 1:50-200 | 1:50-200 |
Product Details
Beclin 1 Antibody (YA6368) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Beclin 1.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 50 kDa
Recombinant human Beclin 1 protein aa 141-450/450
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Beclin 1, also named Atg6, is highly conserved in eukaryotes and belongs to theautophagy-related (Atg) family of proteins. Beclin 1 is a well-established regulator of autophagy, a process essential for mammalian survival. Beclin 1 performs both of its autophagy and membrane trafficking functions by interacting with several other proteins—primarily vacuolar protein sorting-associated protein 15 (VPS15), VPS34, UV radiation resistance-associated gene product (UVRAG), and autophagy-related protein 14 (ATG14) . Together, these assemble into two different Class III PI3K complexes, Complex 1 (C1) and Complex 2 (C2), depending on whether ATG14 or UVRAG respectively is present. Within these complexes, the catalytic lipid kinase subunit, VSP34, is responsible for the phosphorylation of PtdIns, which then mediates autophagy and/or membrane trafficking functions through the recruitment of effector proteins.
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Subcellular Localization
Cytoplasm; Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Endosome membrane; Peripheral membrane protein; Endoplasmic reticulum membrane; Peripheral membrane protein; Mitochondrion membrane; Peripheral membrane protein; Endosome; Cytoplasmic vesicle, autophagosome; Mitochondrion; Nucleus; Cytoplasm; Mitochondrion
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Expression
Tissue_specificity:general expression -
Subunit
A homodimeric form is proposed to exist; this metastable form readily transits to ATG14- or UVRAG-containing complexes with BECN1:UVRAG being more stable than BECN1:ATG14 (By similarity).
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SwissProt ID
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Synonyms
Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN.
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