beta COP Antibody
(Synonyms: COPB, MSTP026, COPB1, Coatomer subunit beta, Beta-coat protein, Beta-COP)beta COP Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to beta COP.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclin950.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:5000-8000 |
Product Details
beta COP Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to beta COP.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 107 kDa
Synthetic peptide of human beta COP (aa 571-620).
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclin950.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
COPB1 is a cytoplasmic protein complex that binds to dilysine motifs and reversibly binds to Golgi non-clathrin-coated vesicles. These vesicles further mediate the transport of biosynthetic proteins from the endoplasmic reticulum via the Golgi apparatus to the trans-Golgi network. The capsid protein complex is essential for Golgi membrane budding and is crucial for the retrograde transport of dilysine-labeled proteins from the Golgi apparatus to the endoplasmic reticulum. In mammals, capsid proteins can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), a class of small GTP-binding proteins; this complex also affects the structural integrity of the Golgi apparatus, as well as the processing, activity, and endocytic circulation of low-density lipoprotein receptors. COPB1 plays a functional role in promoting the transport of κ-opioid receptor mRNA to axons and enhancing the translation of these proteins. COPB1 is essential for limiting lipid storage in lipid droplets.
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Subcellular Localization
Cytoplasm, Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein Curated, Cell membrane
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Isoforms & Post-Translational Modification
COPB1: 953 amino acids, molecular weight 107,142 Da.
CAPN8 undergoes proteolytic cleavage between Ser-528 and Ser-529. -
Subunit
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with COPG1. Interacts (via trunk domain) with ARF1 (via switch I region); the interaction is direct. Interacts with KCNK2/TREK (via N-terminus); this interaction increases the channel-mediated whole cell currents and promotes plasma membrane expression of KCNK2/TREK. Interacts with TMEM115. Interacts with HLA-G-B2M complex; this interaction mediates the endoplasmic reticulum (ER) retrieval of HLA-E-B2M complexes that bind low affinity peptides. Interacts with TMEM41B.
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SwissProt ID
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Synonyms
COPB, MSTP026, COPB1, Coatomer subunit beta, Beta-coat protein, Beta-COP
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