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beta Defensin 1 Antibody (YA1655)

(Synonyms: BD1; beta 1; DEFB1; DEFB101; Defensin; Defensin beta 1; HBD1)
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beta Defensin 1 Antibody (YA1655) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Defensin 1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

beta Defensin 1 Antibody (YA1655) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Defensin 1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 7 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 7 kDa
Species Reactivity Database

Entrez Gene: 1672 Human

SwissProt: P60022 Human

Immunogen

A synthesized peptide derived from human beta Defensin 1 aa30-68/68.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    beta Defensin 1 is a Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility[1].

  • Subcellular Localization

    Secreted; Membrane

  • Expression


    Tissue_specificity:Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia (at protein level)

  • Subunit

    Monomer (PubMed:23938203). Homodimer (PubMed:23938203)

  • SwissProt ID

    P60022

  • Gene ID
    1672 [NCBI]
  • Synonyms

    BD1; beta 1; DEFB1; DEFB101; Defensin; Defensin beta 1; HBD1

  • Research Field

    Immunology

beta Defensin 1 Antibody (YA1655) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • beta Defensin 1 Antibody (YA1655) Product Image