BHLHE41 Antibody (YA8292)
(Synonyms: BHLHB3; DEC2; hDEC2; SHARP1)BHLHE41 Antibody (YA8292) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BHLHE41.
-
Host:
Mouse
-
Isotype:
IgG2a
-
Application:
IHC-P
-
Reactivity :
Human
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
BHLHE41 Antibody (YA8292) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BHLHE41.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 50.3 kDa
Human recombinant protein fragment corresponding to amino acids 1-297 of human BHLHE41 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
BHLHE41 transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11[1][2][3][4][5][6][7].
-
Subcellular Localization
Nucleus
-
Expression
Tissue_Specificity: Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney -
Isoforms & Post-Translational Modification
Q9C0J9: 482 amino acids, molecular weight 50498 Da.
-
Subunit
Homodimer (By similarity)
-
SwissProt ID
-
Synonyms
BHLHB3; DEC2; hDEC2; SHARP1
Documentation
Powered by Bioz
