BSND Antibody (YA7424)
Based on 1 Customer Validation
BSND Antibody (YA7424) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to BSND.
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Host:
Rabbit
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Isotype:
IgG,Kappa
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:1000-1:5000 |
Product Details
BSND Antibody (YA7424) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to BSND.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 35 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 35 kDa
The exact sequence is proprietary to MCE.
Endogenous
Protein A affinity purified
Non-conjugated
Unmodified
IgG,Kappa
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BSND is a Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing. Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates[1][2][3][4][5][6][7][8].
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Subcellular Localization
Basolateral cell membrane
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Expression
Tissue_Specificity: Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear -
Isoforms & Post-Translational Modification
Q8WZ55: 320 amino acids, molecular weight 35197 Da.
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Subunit
Interacts with CLCNK channels
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SwissProt ID
Documentation
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