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Cat. No.: HY-P82423

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c-Myb Antibody (YA2168)

Name: c-Myb Antibody (YA2168)
Brand: MedChemExpress
SKU: HY-P82423
Price: 146.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: MYB; Transcriptional activator Myb; Proto-oncogene c-Myb)

c-Myb Antibody (YA2168) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Myb.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IHC-P
Reactivity :
Human

Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio	1:500-1:1000	1:50-1:100

Product Details

Description

c-Myb Antibody (YA2168) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Myb.

Host Rabbit
Clonality Recombinant, Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 78 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 72 kDa

Species Reactivity Database

Entrez Gene: 4602 Human

SwissProt: P10242 Human

OMIM: 189990 Human

Immunogen

A synthesized peptide derived from human c-Myb aa600-640/640.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

c-Myb transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells
Subcellular Localization

Nucleus
Expression

Induction:Negatively regulated by microRNA-155 (miR-155)
Isoforms & Post-Translational Modification

P10242 has 12 isomers: P10242-1: 72341 Da (predicted); P10242-2: 72032 Da (predicted); P10242-3: 40620 Da (predicted); P10242-4: 85475 Da (predicted); P10242-5: 46065 Da (predicted); P10242-6: 75526 Da (predicted); P10242-7: 85166 Da (predicted); P10242-8: 83626 Da (predicted); P10242-9: 68135 Da (predicted); P10242-10: 68308 Da (predicted); P10242-11: 63198 Da (predicted); P10242-12: 37507 Da (predicted).
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation;SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition;Phosphorylated by NLK on multiple sites, which induces proteasomal degradation;Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels
Subunit

Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1
SwissProt ID

P10242
Gene ID

4602 [NCBI]
Synonyms

MYB; Transcriptional activator Myb; Proto-oncogene c-Myb
Research Field

Epigenetics and Nuclear Signaling