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  4. Monoclonal Antibodies Recombinant Antibodies
  5. c-Myb Antibody (YA2168)

c-Myb Antibody (YA2168)

Cat. No.: HY-P82423
User Guide for Antibodies Technical Support

c-Myb Antibody (YA2168) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Myb.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

c-Myb Antibody (YA2168) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Myb.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 72 kDa;
Observed band size: 78 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human c-Myb aa600-640/640.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells
Subcellular Localization：Nucleus
Expression：
Induction:Negatively regulated by microRNA-155 (miR-155)
Isoforms & Post-Translational Modification：P10242 has 12 isomers: P10242-1: 72341 Da (predicted); P10242-2: 72032 Da (predicted); P10242-3: 40620 Da (predicted); P10242-4: 85475 Da (predicted); P10242-5: 46065 Da (predicted); P10242-6: 75526 Da (predicted); P10242-7: 85166 Da (predicted); P10242-8: 83626 Da (predicted); P10242-9: 68135 Da (predicted); P10242-10: 68308 Da (predicted); P10242-11: 63198 Da (predicted); P10242-12: 37507 Da (predicted).
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation;SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition;Phosphorylated by NLK on multiple sites, which induces proteasomal degradation;Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels
Subunit：Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1
Database

Entrez Gene: 4602 Human

SwissProt: P10242 Human

OMIM: 189990 Human

Research Field

Epigenetics and Nuclear Signaling
Synonyms
MYB; Transcriptional activator Myb; Proto-oncogene c-Myb
Documentation
User Guide for Antibodies (1077 KB)

c-Myb Antibody (YA2168) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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