CBR4 Antibody (YA8659)(PBS only)

Cat. No.: HY-P88975A: Data Sheet User Guide for Antibodies
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CBR4 Antibody (YA8659) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CBR4.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CBR4 Antibody (YA8659) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CBR4.

Host

Mouse

Molecular Weight

Predicted band size: 25.1 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q8N4T8

Immunogen

Full length human recombinant protein of human CBR4 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19000905). As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508)

Subcellular Localization：Mitochondrion matrix

Expression：
Tissue_Specificity: Detected in liver and kidney (at protein level) (PubMed:19000905). Displays the highest expression in neuronal and muscle tissues (PubMed:25203508)

Isoforms & Post-Translational Modification：Q8N4T8 has two isomers: Q8N4T8-1: 25301 Da (predicted); Q8N4T8-2: 18837 Da (predicted).

Subunit：Homotetramer (in vitro) (PubMed:19000905)

Synonyms

SDR45C1

Documentation

User Guide for Antibodies (1077 KB)