DBNL Antibody (YA8640)(PBS only)
(Synonyms: ABP1; HIP-55; HIP55; SH3P7)DBNL Antibody (YA8640) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DBNL.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
DBNL Antibody (YA8640) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DBNL.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 48.1 kDa
Full length human recombinant protein of human DBNL produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DBNL is an Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes
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Subcellular Localization
Cytoplasm, cytoskeleton,Cell projection, lamellipodium,Cell projection, ruffle,Cytoplasm, cell cortex,Cytoplasm, cytosol,Synapse,Perikaryon,Cell projection, neuron projection,Cell membrane,Cytoplasmic vesicle, clathrin-coated vesicle membrane,Golgi apparatus membrane,Cell projection, podosome,Early endosome,Cell projection, dendrite,Postsynaptic density
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Isoforms & Post-Translational Modification
Q9UJU6 has 6 isomers: Q9UJU6-1: 48207 Da (predicted); Q9UJU6-2: 48294 Da (predicted); Q9UJU6-3: 49042 Da (predicted); Q9UJU6-4: 37959 Da (predicted); Q9UJU6-5: 37101 Da (predicted); Q9UJU6-6: 43041 Da (predicted).
Degraded by caspases during apoptosis -
Subunit
Interacts with SHANK2, SHANK3 and SYN1
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SwissProt ID
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Synonyms
ABP1; HIP-55; HIP55; SH3P7
Documentation
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