DDX39A Antibody (YA10108)
(Synonyms: DDX39, DDX39A, ATP-dependent RNA helicase DDX39A, DEAD box protein 39, Nuclear RNA helicase URH49)DDX39A Antibody (YA10108) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to DDX39A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P, IP, IF-Tissue
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol and 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:1000-5000 | 1:200-1000 | 1-2μg/sample |
Product Details
DDX39A Antibody (YA10108) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to DDX39A.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 49 kDa
Synthetic peptide of human DDX39A (aa 1-50).
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol and 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DX39A is a helicase that plays a key role in mRNA export, participating in multiple steps of RNA metabolism, including alternative splicing. DX39A regulates the export of nuclear mRNA to the cytoplasm by binding to its extracellular domain (ECD). Furthermore, it participates in the export of uridine-rich small nuclear RNA (U snRNA) from the spliceosome by stimulating the binding of the adaptor protein PHAX to RNA. DX39A also exerts antiviral effects independently of the interferon pathway by binding to conserved 5' sequence elements in viral genomic RNA[1]>[2].
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Subcellular Localization
Nucleus, Cytoplasm
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Expression
Tissue specificity: Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland.
Induction: Up-regulated in proliferating cells. Present at low levels in quiescent cells. -
Isoforms & Post-Translational Modification
DDX39A has three isomers: O00148-1: 427 amino acids, molecular weight 49,130 Da (predicted); O00148-2: 322 amino acids, molecular weight 36,577 Da (predicted); O00148-3: 267 amino acids, molecular weight 30,488 Da (predicted).
SUMOylation occurs after RANBP2 modification; SUMOylation affects its binding ability to RNA. -
Subunit
Binds ALYREF/THOC4 and DDX39B/BAT1. Interacts with the apo-AREX complex component SARNP. Interacts with MX1. Interacts with MCM3AP isoform GANP. Interacts with ECD. Interacts with PHAX; this interaction stimulates PHAX RNA binding activity.
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SwissProt ID
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Synonyms
DDX39, DDX39A, ATP-dependent RNA helicase DDX39A, DEAD box protein 39, Nuclear RNA helicase URH49
Documentation
References
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