DICER1 Antibody (YA7742)(PBS only)
(Synonyms: DCR1; Dicer; Dicer1e; HERNA; MNG1; RMSE2)DICER1 Antibody (YA7742) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DICER1.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
DICER1 Antibody (YA7742) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DICER1.
-
Host Mouse
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 218.5 kDa
Human recombinant protein fragment corresponding to amino acids 1666-1922 of human DICER1 produced in E.coli.
Affinity purified
Non-conjugated
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
DICER1 is a Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes
-
Subcellular Localization
Cytoplasm,Cytoplasm, perinuclear region
-
Isoforms & Post-Translational Modification
Q9UPY3 has three isomers: Q9UPY3-1: 218682 Da (predicted); Q9UPY3-2: 208448 Da (predicted); Q9UPY3-3: 92726 Da (predicted).
-
Subunit
Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2
-
SwissProt ID
-
Synonyms
DCR1; Dicer; Dicer1e; HERNA; MNG1; RMSE2
Documentation
Powered by Bioz
