DICER1 Antibody (YA7742)(PBS only)

Cat. No.: HY-P88058A: Data Sheet User Guide for Antibodies
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DICER1 Antibody (YA7742) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DICER1.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명
References

제품 설명

DICER1 Antibody (YA7742) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DICER1.

Host

Mouse

분자량

Predicted band size: 218.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9UPY3

Immunogen

Human recombinant protein fragment corresponding to amino acids 1666-1922 of human DICER1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes

Subcellular Localization：Cytoplasm,Cytoplasm, perinuclear region

Isoforms & Post-Translational Modification：Q9UPY3 has three isomers: Q9UPY3-1: 218682 Da (predicted); Q9UPY3-2: 208448 Da (predicted); Q9UPY3-3: 92726 Da (predicted).

Subunit：Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2

Synonyms

DCR1; Dicer; Dicer1e; HERNA; MNG1; RMSE2

각종 서류

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/huvec-cell.html [Content Brief]