DLX1 Antibody (YA7839)
(Synonyms: distal-less homeo box 1; distal-less homeobox 1)DLX1 Antibody (YA7839) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DLX1.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
DLX1 Antibody (YA7839) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DLX1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
Human recombinant protein fragment corresponding to amino acids 1-255 of human DLX1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DLX1 plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in hematopoietic cell lines -
Isoforms & Post-Translational Modification
P56177 has two isomers: P56177-1: 27320 Da (predicted); P56177-2: 13521 Da (predicted).
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Subunit
Interacts with SMAD4 (via homeobox DNA-binding domain) (PubMed:14671321)
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SwissProt ID
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Synonyms
distal-less homeo box 1; distal-less homeobox 1
Documentation
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