DNA Polymerase lambda Antibody (YA6930)

Cat. No.: HY-P87242: Data Sheet User Guide for Antibodies
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DNA Polymerase lambda Antibody (YA6930) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNA Polymerase lambda.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

DNA Polymerase lambda Antibody (YA6930) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNA Polymerase lambda.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size：63 kDa;

Observed band size: 70 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Monkey

SwissProt ID

Q9UGP5

Immunogen

Recombinant protein within human DNA Polymerase lambda aa 1-575 / 575.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:1000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195)

Subcellular Localization：Nucleus,Chromosome

Expression：
Tissue_Specificity: Expressed in a number of tissues. Abundant in testis

Isoforms & Post-Translational Modification：Q9UGP5 has two isomers: Q9UGP5-1: 63482 Da (predicted); Q9UGP5-2: 33839 Da (predicted).

Subunit：Interacts with PCNA (PubMed:14992725)

Synonyms

BETA N antibody

Documentation

User Guide for Antibodies (1077 KB)