DPTOR Antibody (YA6924)
(Synonyms: DEP domain containing 6 antibody)DPTOR Antibody (YA6924) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPTOR.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:200 |
Product Details
DPTOR Antibody (YA6924) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPTOR.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 46 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size：46 kDa
Recombinant protein within human DPTOR aa 1-300.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DPTOR is a Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity[1][2][3][4][5][6][7][8].
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Subcellular Localization
Lysosome membrane
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Expression
Induction: Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level)
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Isoforms & Post-Translational Modification
Q8TB45 has two isomers: Q8TB45-1: 46294 Da (predicted); Q8TB45-2: 34006 Da (predicted).
Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2 (PubMed:19446321)丨Ubiquitinated; leading to proteasomal degradation (PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:30080879, PubMed:33110214) -
Subunit
Associated component of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR (PubMed:19446321, PubMed:25936805, PubMed:34519268, PubMed:34519269)
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SwissProt ID
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Synonyms
DEP domain containing 6 antibody
Documentation
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