Ferritin Light Chain Antibody (YA5300)
(Synonyms: Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide; Ferritin light polypeptide like 3; FRIL; FRIL_HUMAN; FTL; L apoferritin; LFTD; MGC71996; NBIA 3; NBIA3.)Ferritin Light Chain Antibody (YA5300) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ferritin Light Chain.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, IF-Tissue
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:100-200 | 1:50-200 |
Product Details
Ferritin Light Chain Antibody (YA5300) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ferritin Light Chain.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 20 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Purified recombinant full length of human ferritin light chain protein expressed in E.coli.
Endogenous
affinity chromatography.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Ferritin Light Chain is a Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron[1].
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Subcellular Localization
Cytoplasmic vesicle, autophagosome; Cytoplasm; Autolysosome
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Subunit
Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Iron enters the spherical protein shell through pores that are formed between subunits. Mutations leading to truncation or the addition of extra residues at the C-terminus interfere with normal pore formation and with iron accumulation. Interacts with NCOA4 (PubMed:24695223)
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SwissProt ID
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Synonyms
Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide; Ferritin light polypeptide like 3; FRIL; FRIL_HUMAN; FTL; L apoferritin; LFTD; MGC71996; NBIA 3; NBIA3.
Documentation
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