FKBP6 Antibody (YA2920)(PBS only)
(Synonyms: FKBP36)FKBP6 Antibody (YA2920) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP6.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
FKBP6 Antibody (YA2920) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP6.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 37 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 37 kDa
A synthetic peptide of human FKBP6
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FKBP6 is a Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes[1].
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_specificity:Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney -
Isoforms & Post-Translational Modification
O75344 has 3 isomers: O75344-1: 37214 Da (predicted); O75344-2: 36874 Da (predicted); O75344-3: 33553 Da (predicted).
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Subunit
Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity
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SwissProt ID
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Synonyms
FKBP36
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Research Field
Immunology
Documentation
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