FKBP6 Antibody (YA2920)(PBS only)

Cat. No.: HY-P83175A: Data Sheet User Guide for Antibodies
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FKBP6 Antibody (YA2920) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP6.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

FKBP6 Antibody (YA2920) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP6.

Host

Rabbit

Molecular Weight

Predicted band size: 37 kDa;

Observed band size: 37 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O75344

Gene ID

8468 [NCBI]

Immunogen

A synthetic peptide of human FKBP6

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Has an essential role in spermatogenesis (PubMed:36150389). It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity)

Subcellular Localization：Cytoplasm; Nucleus

Expression：
Tissue_specificity:Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney

Isoforms & Post-Translational Modification：O75344 has 3 isomers: O75344-1: 37214 Da (predicted); O75344-2: 36874 Da (predicted); O75344-3: 33553 Da (predicted).

Subunit：Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity

Research Field

Immunology

Synonyms

FKBP36

Documentation

User Guide for Antibodies (1077 KB)