FOXP1 Antibody (YA5799)
(Synonyms: FOXP1; HSPC215; Forkhead box protein P1)
Based on 1 Customer Validation
FOXP1 Antibody (YA5799) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXP1.
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Host:
Rabbit
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Isotype:
IgG/Kappa
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Application:
WB, IHC-P, ICC/IF, IP, ELISA
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:4000 | 1:1000-1:5000 | 1:200-1:1000 | 1:5000-1:20000 | 1:50-1:200 |
Product Details
FOXP1 Antibody (YA5799) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXP1.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 82-90 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 75 kDa
Protein A
Non-conjugated
Unmodified
IgG/Kappa
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FOXP1 belongs to the forkhead box protein P (FOXP) family. FOXP1 is highly expressed in the nervous system and regulate molecular pathways required for proper brain development and function. FOXP1 regulates development of B cells. FOXP1 has protein-protein interaction with NFAT1 to enhance breast cancer cell motility. Furthermore, overexpression of FOXP1 inhibits proliferation and invasion in U251 glioma cells, while knockdown of FOXP1 promotes the development of lung carcinoma. FOXP1 is also known to interact with FOXP3 through NFAT-IL-2 promoter DNA complexes[1][2].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Isomer 8 is specifically expressed in embryonic stem cells.
Induction:By androgen in an isoform-specific manner; expression of isoform 4 is greatly induced -
Subunit
Forms homodimers and heterodimers with FOXP2 and FOXP4 (PubMed:25027557). Dimerization is required for DNA-binding. Self-associates (PubMed:26647308).
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SwissProt ID
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Synonyms
FOXP1; HSPC215; Forkhead box protein P1
Documentation
References
[1]. Co M, et al. FOXP transcription factors in vertebrate brain development, function, and disorders. Wiley Interdiscip Rev Dev Biol. 2020 Sep;9(5):e375. [Content Brief]
[2]. Kim JH, et al. Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression. Mol Cancer. 2019 Dec 9;18(1):180. [Content Brief]
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