FOXP1 - forkhead box P1 Gene

Also Known as MFH; QRF1; 12CC4; hFKH1B; HSPC215

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27086

About FOXP1

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:70,954,708-71,583,978 (from NCBI)

This gene has 71 transcripts (splice variants), 131 orthologues, 42 paralogues and is associated with 104 phenotypes. Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues.

Summary

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

FOXP1 Products (17)

mRNA	Protein	Name
NM_001012505.2	NP_001012523.1	forkhead box protein P1 isoform b
NM_001244808.3	NP_001231737.1	forkhead box protein P1 isoform c
NM_001244810.2	NP_001231739.1	forkhead box protein P1 isoform d
NM_001244812.3	NP_001231741.1	forkhead box protein P1 isoform e
NM_001244813.3	NP_001231742.1	forkhead box protein P1 isoform f
NM_001244814.3	NP_001231743.1	forkhead box protein P1 isoform a
NM_001244815.2	NP_001231744.2	forkhead box protein P1 isoform f
NM_001244816.2	NP_001231745.1	forkhead box protein P1 isoform a
NM_001349337.2	NP_001336266.2	forkhead box protein P1 isoform i
NM_001349338.3	NP_001336267.1	forkhead box protein P1 isoform a
NM_001349340.3	NP_001336269.1	forkhead box protein P1 isoform a
NM_001349341.3	NP_001336270.1	forkhead box protein P1 isoform j
NM_001349342.3	NP_001336271.1	forkhead box protein P1 isoform f
NM_001349343.3	NP_001336272.1	forkhead box protein P1 isoform i
NM_001349344.3	NP_001336273.1	forkhead box protein P1 isoform i
NM_001370548.1	NP_001357477.1	forkhead box protein P1 isoform k
NM_032682.6	NP_116071.2	forkhead box protein P1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28218735	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25609649	GOA
enables nuclear androgen receptor binding	IDA IDA: Inferred from direct assay	18640093	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18347093	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	30111844	GOA
involved in endothelial cell activation	IMP IMP: Inferred from mutant phenotype	24023716	GOA
involved in macrophage activation	IDA IDA: Inferred from direct assay	18799727	GOA
involved in monocyte activation	IDA IDA: Inferred from direct assay	18799727	GOA
involved in negative regulation of B cell apoptotic process	IDA IDA: Inferred from direct assay	25267198	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20950788	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	26647308	GOA
involved in negative regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	18640093	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	30111844	GOA
involved in osteoclast development	IDA IDA: Inferred from direct assay	18799727	GOA
involved in osteoclast differentiation	IDA IDA: Inferred from direct assay	18799727	GOA
involved in positive regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	30111844	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24023716	GOA
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	24023716	GOA
involved in regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of defense response to bacterium	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of endothelial tube morphogenesis	IMP IMP: Inferred from mutant phenotype	24023716	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28218735	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of monocyte differentiation	IDA IDA: Inferred from direct assay	15286807	GOA
involved in regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	18799727	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	25027557	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXP1 Protein Structure

Forkhead

0
200
400
600
677 a.a.

Protein Preferred Names	Protein Names
forkhead box protein P1	fork head-related protein like B

FOXP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOXP1	Q9H334	FOXP4	Homo sapiens	Q8IVH2	IF	25027557
Intra	FOXP1	Q9H334	FOXP4	Homo sapiens	Q8IVH2	TAP	25609649
Intra	FOXP1	Q9H334	FOXP4	Homo sapiens	Q8IVH2	Anti Tag CoIP	25027557
Intra	FOXP1	Q9H334	FOXP2	Homo sapiens	O15409	TAP	25609649
Intra	FOXP1	Q9H334	FOXP2	Homo sapiens	O15409	Anti Tag CoIP	25027557
Intra	FOXP1	Q9H334	FOXP2	Homo sapiens	O15409	IF	25027557
Intra	FOXP1	Q9H334	FOXP2	Homo sapiens	O15409	IF	25853299
Intra	FOXP1	Q9H334	FOXP1	Homo sapiens	Q9H334	Confocal	26647308
Intra	FOXP1	Q9H334	FOXP1	Homo sapiens	Q9H334	IF	25853299
Intra	FOXP1	Q9H334	FOXP1	Homo sapiens	Q9H334	BRET	25853299
Intra	FOXP1	Q9H334	FOXP1	Homo sapiens	Q9H334	TAP	25609649
Intra	FOXP1	Q9H334	FOXP1	Homo sapiens	Q9H334	BRET	26647308

Cross: Cross-species interaction Intra: Intraspecies interaction

FOXP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81538	FOXP1 Antibody (YA1283)	IHC-P	Human
HY-P81538A	FOXP1 Antibody (YA1283)(PBS only)	IHC-P	Human
HY-P86107	FOXP1 Antibody (YA5799)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome	Foxp1 Syndrome Mental Retardation With Language Impairment And With Or Without Autistic Features Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects Intellectual Disability With Language Impairment And With Or Without Autistic Features
Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features	Mental Retardation With Language Impairment And With Or Without Autistic Features Intellectual Developmental Disorder With Language Impairment With Or Without Autistic Features MRLIAF
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Atrial Septal Defect 1	ASD1 Atrial Heart Septal Defect 1 Asd
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Earlobe Crease
Rare Genetic Intellectual Disability
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Speech Disorder	Speech Disorders
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
B-Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like	B Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like B-All Bcr-Abl1-Like
Blepharophimosis
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia	HH4 Kallmann Syndrome 4 Kal4 Hypogonadotropic Hypogonadism, Type 4 With/Without Anosmia
Megalencephaly	Macroencephaly Macrencephaly
Alpha Chain Disease	Seligmann'S Disease Immunoproliferative Small Intestinal Disease
Orbit Lymphoma	Orbital Lymphoma Lymphoma Of The Orbit
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Congenital Disorder Of Glycosylation, Type Ig	CDG1G Alg12-Congenital Disorder Of Glycosylation Cdg Ig Congenital Disorder Of Glycosylation Type 1g Congenital Disorder Of Glycosylation Type Ig Cdgig Congenital Disorder Of Glycosylation Ig Congenital Disorder Of Glycosylation 1g Cdg-Ig Alg12-Cdg Cdg Syndrome Type Ig Carbohydrate Deficient Glycoprotein Syndrome Type Ig Mannosyltransferase 8 Deficiency Glycosylation, Congenital Disorder Of, Type Ig
Marginal Zone B-Cell Lymphoma	Marginal Zone Lymphoma Mzl Mucosa-Associated Lymphoid Tissue Lymphoma
Specific Language Impairment	Language Impairment, Specific
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05073	FOXP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19683	Foxp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26176	Foxp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FOXP1	VGNC	VGNC:29101
Felis catus	FOXP1	VGNC	VGNC:62345
Mus musculus	FOXP1	MGD	MGI:1914004
Rattus norvegicus	FOXP1	RGD	RGD:1308669
Canis familiaris	FOXP1	VGNC	VGNC:40965
Macaca mulatta	FOXP1	VGNC	VGNC:84173
Others	FOXP1	NCBI