Fukutin Antibody (YA6576)
(Synonyms: CMD1X antibody; FCMD antibody; FCMD gene antibody; FKTN antibody; FKTN_HUMAN antibody; Fukutin antibody; Fukuyama type congenital muscular dystrophy protein antibody; Fukuyama-type congenital muscular dystrophy protein antibody; LGMD2M antibody; MDDGA4 antibody; CMD1X antibody; FCMD antibody; FCMD gene antibody; FKTN antibody; FKTN_HUMAN antibody; Fukutin antibody; Fukuyama type congenital muscular dystrophy protein antibody; Fukuyama-type congenital muscular dystrophy protein antibody; LGMD2M antibody; MDDGA4 antibody; MDDGB4 antibody; MDDGC4 antibody; MGC126857 antibody; MGC134944 antibody; MGC134945 antibody; MGC138243 antibody; OTTHUMP00000021841 antibody; patient fukutin antibody; )
Based on 1 Customer Validation
Fukutin Antibody (YA6576) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fukutin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:5000 | 1:50-1:200 |
Product Details
Fukutin Antibody (YA6576) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fukutin.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 54 kDa
Recombinant protein within human Fukutin aa 312-461/461.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Fukutin catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable)[1][2][3][4][5].
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Subcellular Localization
Golgi apparatus membrane,Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Expressed in the retina (at protein level) (PubMed:29416295). Widely expressed with highest expression in brain, heart, pancreas and skeletal muscle (PubMed:11115853). Expressed at similar levels in control fetal and adult brain (PubMed:11115853). Expressed in migrating neurons, including Cajar-Retzius cells and adult cortical neurons, as well as hippocampal pyramidal cells and cerebellar Purkinje cells (PubMed:11115853). No expression observed in the glia limitans, the subpial astrocytes (which contribute to basement membrane formation) or other glial cells (PubMed:11115853) -
Isoforms & Post-Translational Modification
O75072 has two isomers: O75072-1: 53724 Da (predicted); O75072-2: 49832 Da (predicted).
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Subunit
Forms a complex composed of FKTN/fukutin, FKRP and RXYLT1/TMEM5 (PubMed:29477842)
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SwissProt ID
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Synonyms
CMD1X antibody; FCMD antibody; FCMD gene antibody; FKTN antibody; FKTN_HUMAN antibody; Fukutin antibody; Fukuyama type congenital muscular dystrophy protein antibody; Fukuyama-type congenital muscular dystrophy protein antibody; LGMD2M antibody; MDDGA4 antibody; CMD1X antibody; FCMD antibody; FCMD gene antibody; FKTN antibody; FKTN_HUMAN antibody; Fukutin antibody; Fukuyama type congenital muscular dystrophy protein antibody; Fukuyama-type congenital muscular dystrophy protein antibody; LGMD2M antibody; MDDGA4 antibody; MDDGB4 antibody; MDDGC4 antibody; MGC126857 antibody; MGC134944 antibody; MGC134945 antibody; MGC138243 antibody; OTTHUMP00000021841 antibody; patient fukutin antibody;
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