Fukutin Antibody (YA6576)

Cat. No.: HY-P86883: Data Sheet COA
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Fukutin Antibody (YA6576) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fukutin.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Fukutin Antibody (YA6576) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fukutin.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 54 kDa;

Observed band size: 50 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O75072

Gene ID

2218 [NCBI]

Immunogen

Recombinant protein within human Fukutin aa 312-461/461.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:5000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:200

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:26923585, PubMed:27194101, PubMed:29477842). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:27194101, PubMed:29477842). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:17034757). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:25279699). Could be involved in brain development (Probable)

Subcellular Localization：Golgi apparatus membrane,Cytoplasm,Nucleus

Expression：
Tissue_Specificity: Expressed in the retina (at protein level) (PubMed:29416295). Widely expressed with highest expression in brain, heart, pancreas and skeletal muscle (PubMed:11115853). Expressed at similar levels in control fetal and adult brain (PubMed:11115853). Expressed in migrating neurons, including Cajar-Retzius cells and adult cortical neurons, as well as hippocampal pyramidal cells and cerebellar Purkinje cells (PubMed:11115853). No expression observed in the glia limitans, the subpial astrocytes (which contribute to basement membrane formation) or other glial cells (PubMed:11115853)

Isoforms & Post-Translational Modification：O75072 has two isomers: O75072-1: 53724 Da (predicted); O75072-2: 49832 Da (predicted).

Subunit：Forms a complex composed of FKTN/fukutin, FKRP and RXYLT1/TMEM5 (PubMed:29477842)

Synonyms

CMD1X antibody; FCMD antibody; FCMD gene antibody; FKTN antibody; FKTN_HUMAN antibody; Fukutin antibody; Fukuyama type congenital muscular dystrophy protein antibody; Fukuyama-type congenital muscular dystrophy protein antibody; LGMD2M antibody; MDDGA4 antibody; CMD1X antibody; FCMD antibody; FCMD gene antibody; FKTN antibody; FKTN_HUMAN antibody; Fukutin antibody; Fukuyama type congenital muscular dystrophy protein antibody; Fukuyama-type congenital muscular dystrophy protein antibody; LGMD2M antibody; MDDGA4 antibody; MDDGB4 antibody; MDDGC4 antibody; MGC126857 antibody; MGC134944 antibody; MGC134945 antibody; MGC138243 antibody; OTTHUMP00000021841 antibody; patient fukutin antibody;

Documentation

Select Batch:

Data Sheet (231 KB) SDS (254 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)