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Cat. No.: HY-P87627

GAT1 Antibody (YA7311)

GAT1 Antibody (YA7311) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GAT1.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	IF-Tissue IF-Tissue: Immunofluorescence-Tissue
Dilution Ratio	1:100-500	1:100-500	1:100-500

Description

GAT1 Antibody (YA7311) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GAT1.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 67 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 67 kDa

Immunogen

A synthesized peptide derived from human GAT 1

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

GAT1 mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA. The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA. Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA^[1].
Subcellular Localization

Cell membrane,Presynapse
Isoforms & Post-Translational Modification

P30531: 599 amino acids, molecular weight 67074 Da.
Subunit

Interacts (via PDZ domain-binding motif) with PALS1; interaction increases SLC6A1-mediated GABA uptake
SwissProt ID

P30531