GOLGA1 Antibody (YA2948)
(Synonyms: Golgin subfamily A member 1 (Golgin-97))Based on 1 Customer Validation
GOLGA1 Antibody (YA2948) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GOLGA1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:2000-1:5000 |
Product Details
GOLGA1 Antibody (YA2948) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GOLGA1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 88 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 88 kDa
A synthetic peptide of human Golgin 97
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GOLGA1 is involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23. Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers; (Microbial infection) Plays an important role in poxvirus morphogenesis. Translocates into the viral factories where it may transport the membrane fragments and associated protein factors important for virus maturation to the sites of virion assembly[1][2][3].
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Subcellular Localization
Golgi apparatus membrane; Peripheral membrane protein; Golgi apparatus, trans-Golgi network membrane; Cytoplasmic vesicle, secretory vesicle, acrosome
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Subunit
Interacts with RAB6A (PubMed:10209123). Directly interacts with TBC1D23 (PubMed:29084197, PubMed:38552021). Interacts with FAM91A1; this interaction may be mediated by TBC1D23 (PubMed:29084197). Interacts with ARL1; this interaction recruits Golgin-97/GOLGA1 onto the Golgi apparatus (PubMed:12972563)
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SwissProt ID
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Synonyms
Golgin subfamily A member 1 (Golgin-97)
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Research Field
Tags & Cell Markers
Documentation
References
[1]. Shin JJH, et al. TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi. Nat Cell Biol. 2017 Dec;19(12):1424-1432. [Content Brief]
[2]. Cattin-Ortolá J, et al. Cargo selective vesicle tethering: The structural basis for binding of specific cargo proteins by the Golgi tether component TBC1D23. Sci Adv. 2024 Mar 29;10(13):eadl0608. [Content Brief]
[3]. Grimaldi G, et al. PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):. [Content Brief]
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