GPR182 Antibody (YA2961)(PBS only)
(Synonyms: AMR; 7TMR; ADMR; AM-R; G10D; L1-R; gamrh; hrhAMR)GPR182 Antibody (YA2961) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPR182.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
GPR182 Antibody (YA2961) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPR182.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 45 kDa
Recombinant protein of human GPR182
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GPR182 is an atypical chemokine receptor that regulates chemokine levels and localization by binding to them, without relying on the activation of classical ligand-induced signaling pathways. GPR182 mediates the sequestration, transport, or endocytosis of chemokines, thereby controlling their bioavailability. GPR182 functions as a scavenger receptor for various chemokines, including CXCL9, CXCL10, CXCL12, CXCL13, CXCL11, CXCL14, CCL1, CCL11, CCL19, CCL25, CCL28, and XCL1. GPR182 is the sole atypical receptor for the chemokines CXCL13 and CCL28. GPR182 exhibits strong constitutive binding to β-arrestin; this interaction is crucial for receptor intracellular trafficking and chemokine scavenging, and it occurs independently of ligand binding. GPR182 acts in concert with ACKR3 and ACKR4 to regulate the serum levels of CXCL12 and CCL19, respectively.
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Endosome membrane
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Expression
Tissue_specificity:Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver -
Subunit
Strong constitutive association with beta-arrestins; leading to internalization of ACKR5 and its ligands.
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SwissProt ID
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Synonyms
AMR; 7TMR; ADMR; AM-R; G10D; L1-R; gamrh; hrhAMR
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Research Field
Signal Transduction
Documentation
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