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HBS1L Antibody (YA8203)(PBS only)

(Synonyms: EF-1a; eRF3c; ERFS; HBS1; HSPC276)

HBS1L Antibody (YA8203) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HBS1L.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • HBS1L Antibody (YA8203)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-800

Product Details

Description

HBS1L Antibody (YA8203) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HBS1L.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 75.3 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-260 of human HBS1L produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    HBS1L is a GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway[1][2][3][4].

  • Subcellular Localization

    Cytoplasm,Cytoplasm

  • Expression


    Tissue_Specificity: Detected in heart, brain, placenta, liver, muscle, kidney and pancreas

  • Isoforms & Post-Translational Modification

    Q9Y450 has three isomers: Q9Y450-1: 75473 Da (predicted); Q9Y450-2: 70128 Da (predicted); Q9Y450-4: 70625 Da (predicted).

  • Subunit

    Component of the Pelota-HBS1L complex, also named Dom34-Hbs1 complex, composed of PELO and HBS1L (PubMed:27863242)

  • SwissProt ID

    Q9Y450

  • Synonyms

    EF-1a; eRF3c; ERFS; HBS1; HSPC276

HBS1L Antibody (YA8203)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • HBS1L Antibody (YA8203)(PBS only) Product Image