HCN1 Antibody
(Synonyms: BCNG1, HCN1, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1, BCNG-1)HCN1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to HCN1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P
-
Reactivity :
Human, Mouse
-
Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
HCN1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to HCN1.
-
Host Rabbit
-
Clonality Polyclonal
-
Species ReactivityHuman, Mouse
-
Observed Molecular WeightObserved band size: 99 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 98 kDa
Synthetic peptide of human HCN1
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
HCN1 is a Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability. Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (By similarity)[1][2][3][4].
-
Subcellular Localization
Cell membrane
-
Expression
Tissue_Specificity: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. -
Isoforms & Post-Translational Modification
HCN1 has an amino acid length of 890, molecular weight is 98796 Da.
-
Subunit
Homotetramer.
-
SwissProt ID
-
Synonyms
BCNG1, HCN1, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1, BCNG-1
Documentation
[1]. Gill CH, et al. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 2004 Oct;143(3):411-21. [Content Brief]
[2]. Lee CH, et al. Structures of the Human HCN1 Hyperpolarization-Activated Channel. Cell. 2017 Jan 12;168(1-2):111-120.e11. [Content Brief]
[3]. Bonzanni M, et al. A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability. Neurobiol Dis. 2018 Oct;118:55-63. [Content Brief]
[4]. Marini C, et al. HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond. Brain. 2018 Nov 1;141(11):3160-3178. [Content Brief]
Powered by Bioz
