Hepcidin Antibody (YA6601)
(Synonyms: Hamp antibody; HEPC antibody; HEPC_HUMAN antibody; Hepc20 antibody; Hepc25 antibody; Hepcidin-20 antibody; HFE2B antibody; LEAP-1 antibody; LEAP1 antibody; Liver-expressed antimicrobial peptide 1 antibody; Hamp antibody; HEPC antibody; HEPC_HUMAN antibody; Hepc20 antibody; Hepc25 antibody; Hepcidin-20 antibody; HFE2B antibody; LEAP-1 antibody; LEAP1 antibody; Liver-expressed antimicrobial peptide 1 antibody; PLTR antibody; Putative liver tumor regressor antibody; )
Based on 1 Customer Validation
Hepcidin Antibody (YA6601) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hepcidin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Rat
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:50-1:200 |
Product Details
Hepcidin Antibody (YA6601) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hepcidin.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 25kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 9kDa
Recombinant protein within Hepcidin aa 1-84 / 84.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Hepcidin is a 25-amino-acid peptide hormone secreted by hepatocytes. Hepcidin determines plasma iron concentrations and total body iron content. The function of hepcidin is to control the activity of the cellular iron exporter ferroportin, which delivers iron to plasma from intestinal iron absorption and from iron stores.
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood (PubMed:11034317). Expressed by hepatocytes (PubMed:15124018)
Induction: Expression in hepatocytes is induced by LPS stimulus and the induction is mediated by IL6 (PubMed:15124018). Expression is inhibited in presence of TNF (PubMed:15124018) -
Isoforms & Post-Translational Modification
P81172: 84 amino acids, molecular weight 9408 Da.
Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity)丨O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status丨S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex -
Subunit
Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination
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SwissProt ID
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Synonyms
Hamp antibody; HEPC antibody; HEPC_HUMAN antibody; Hepc20 antibody; Hepc25 antibody; Hepcidin-20 antibody; HFE2B antibody; LEAP-1 antibody; LEAP1 antibody; Liver-expressed antimicrobial peptide 1 antibody; Hamp antibody; HEPC antibody; HEPC_HUMAN antibody; Hepc20 antibody; Hepc25 antibody; Hepcidin-20 antibody; HFE2B antibody; LEAP-1 antibody; LEAP1 antibody; Liver-expressed antimicrobial peptide 1 antibody; PLTR antibody; Putative liver tumor regressor antibody;
Documentation
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