HNRNPL Antibody (YA7745)(PBS only)
(Synonyms: hnRNP-L; HNRPL)HNRNPL Antibody (YA7745) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HNRNPL.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
HNRNPL Antibody (YA7745) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HNRNPL.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 64 kDa
Human recombinant protein fragment corresponding to amino acids 270-502 of human HNRNPL produced in E.coli.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HNRNPL is a Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8[1][2][3][4][5][6][7].
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Subcellular Localization
Nucleus, nucleoplasm,Cytoplasm
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Isoforms & Post-Translational Modification
P14866 has two isomers: P14866-1: 64133 Da (predicted); P14866-2: 50561 Da (predicted).
Several isoelectric forms of the L protein are probably the results of post-translational modifications丨Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization -
Subunit
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661)
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SwissProt ID
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Synonyms
hnRNP-L; HNRPL
Documentation
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