HNRNPL Antibody (YA7745)(PBS only)

製品番号: HY-P88061A: データシート User Guide for Antibodies
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HNRNPL Antibody (YA7745) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HNRNPL.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

HNRNPL Antibody (YA7745) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HNRNPL.

Host

Mouse

分子量

Predicted band size: 64 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P14866

Immunogen

Human recombinant protein fragment corresponding to amino acids 270-502 of human HNRNPL produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

純度	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8

Subcellular Localization：Nucleus, nucleoplasm,Cytoplasm

Isoforms & Post-Translational Modification：P14866 has two isomers: P14866-1: 64133 Da (predicted); P14866-2: 50561 Da (predicted).
Several isoelectric forms of the L protein are probably the results of post-translational modifications丨Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization

Subunit：Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661)

Synonyms

hnRNP-L; HNRPL

ドキュメンテーション

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/cv-1-cell.html [Content Brief]