HOP Antibody
(Synonyms: HOD, HOP, LAGY, NECC1, OB1, HOPX, Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1)HOP Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to HOP.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
HOP Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to HOP.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 11 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 8 kDa
Synthetic peptide corresponding to the Central region of human HOP.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HOP is an Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding[1].
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_Specificity: Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma. -
Isoforms & Post-Translational Modification
HOP has 4 isoforms, Q9BPY8-1: amino acid length is 73, molecular weight is 8260 Da (predicted); Q9BPY8-2: amino acid length is 94, molecular weight is 10459 Da (predicted); Q9BPY8-3: amino acid length is 91, molecular weight is 10427 Da (predicted); Q9BPY8-4: amino acid length is 112, molecular weight is 12625 Da (predicted).
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Subunit
Interacts with serum response factor (SRF).
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SwissProt ID
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Synonyms
HOD, HOP, LAGY, NECC1, OB1, HOPX, Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1
Documentation
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