Human IgG4 Antibody (YA3327)(PBS only)
(Synonyms: IGG4; Ig gamma 4 chain C region)Human IgG4 Antibody (YA3327) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Human IgG4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
Human IgG4 Antibody (YA3327) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Human IgG4.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 36 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 36 kDa
A synthesized peptide derived from human IgG4 aa95-109.
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Human IgG4 is a Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen[1][2][3].
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Subcellular Localization
Secreted; Cell membrane; Single-pass membrane protein
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Isoforms & Post-Translational Modification
P01861 has 2 isomers: P01861-2: 43832 Da (predicted); P01861-1: 35941 Da (predicted).
Glycosylation on Asn-177 is required for interaction with Fc receptors and ability to activate the complement pathway;(Microbial infection) Deglycosylation on Asn-177 by S.pyogenes EndoS or Endos2 endoglucosidases prevents interaction between immunoglobulin-gamma (IgG) and Fc receptors, impairing ability to activate the complement pathway -
Subunit
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked
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SwissProt ID
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Synonyms
IGG4; Ig gamma 4 chain C region
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Research Field
Immunology
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