ICER Antibody
(Synonyms: cAMP-responsive element modulator, Inducible cAMP early repressor, ICER, CREM)ICER Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ICER.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
ICER Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ICER.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 35 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 37 kDa
Synthetic peptide corresponding to the center region of human ICER.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ICER is a Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. -
Isoforms & Post-Translational Modification
ICER has 29 isoforms, Q03060-5: amino acid length is 345, molecular weight is 37006 Da (predicted); Q03060-1: amino acid length is 349, molecular weight is 37628 Da (predicted); Q03060-6: amino acid length is 348, molecular weight is 37577 Da (predicted); Q03060-2: amino acid length is 237, molecular weight is 26320 Da (predicted); Q03060-7: amino acid length is 245, molecular weight is 26513 Da (predicted); Q03060-8: amino acid length is 120, molecular weight is 13435 Da (predicted); Q03060-9: amino acid length is 108, molecular weight is 12124 Da (predicted); Q03060-10: amino acid length is 121, molecular weight is 13486 Da (predicted); Q03060-11: amino acid length is 109, molecular weight is 12175 Da (predicted); Q03060-12: amino acid length is 270, molecular weight is 29656 Da (predicted); Q03060-13: amino acid length is 219, molecular weight is 24774 Da (predicted); Q03060-14: amino acid length is 194, molecular weight is 21630 Da (predicted); Q03060-15: amino acid length is 312, molecular weight is 33825 Da (predicted); Q03060-16: amino acid length is 300, molecular weight is 32514 Da (predicted); Q03060-17: amino acid length is 221, molecular weight is 23839 Da (predicted); Q03060-19: amino acid length is 170, molecular weight is 18927 Da (predicted); Q03060-20: amino acid length is 286, molecular weight is 31405 Da (predicted); Q03060-21: amino acid length is 285, molecular weight is 31354 Da (predicted); Q03060-22: amino acid length is 282, molecular weight is 30968 Da (predicted); Q03060-23: amino acid length is 102, molecular weight is 11535 Da (predicted); Q03060-24: amino acid length is 112, molecular weight is 12679 Da (predicted); Q03060-25: amino acid length is 137, molecular weight is 14871 Da (predicted); Q03060-26: amino acid length is 248, molecular weight is 27549 Da (predicted); Q03060-27: amino acid length is 113, molecular weight is 12730 Da (predicted); Q03060-28: amino acid length is 138, molecular weight is 15116 Da (predicted); Q03060-29: amino acid length is 125, molecular weight is 14041 Da (predicted); Q03060-30: amino acid length is 221, molecular weight is 24385 Da (predicted); Q03060-31: amino acid length is 299, molecular weight is 32463 Da (predicted); Q03060-32: amino acid length is 236, molecular weight is 26269 Da (predicted).Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome
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Subunit
Binds DNA as a dimer.
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SwissProt ID
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Synonyms
cAMP-responsive element modulator, Inducible cAMP early repressor, ICER, CREM
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