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ICT1 Antibody (YA8673)(PBS only)

(Synonyms: DS-1; DS1; ICT1; MRP-L58)

ICT1 Antibody (YA8673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ICT1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • ICT1 Antibody (YA8673)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

ICT1 Antibody (YA8673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ICT1.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 23.4 kDa
Immunogen

Full length human recombinant protein of human ICT1 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ICT1 is essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes[1][2].

  • Subcellular Localization

    Mitochondrion

  • Expression


    Tissue_Specificity: Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells

  • Isoforms & Post-Translational Modification

    Q14197: 206 amino acids, molecular weight 23630 Da.

  • Subunit

    Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:20186120, PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605)

  • SwissProt ID

    Q14197

  • Synonyms

    DS-1; DS1; ICT1; MRP-L58

ICT1 Antibody (YA8673)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • ICT1 Antibody (YA8673)(PBS only) Product Image