IFNGR2 Antibody (YA7895)(PBS only)
(Synonyms: AF-1; IFGR2; IFNGT1; IMD28)IFNGR2 Antibody (YA7895) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to IFNGR2.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
IFNGR2 Antibody (YA7895) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to IFNGR2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 35 kDa
Full length human recombinant protein of human IFNGR2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IFNGR2 associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding[1][2][3][4].
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Subcellular Localization
Cell membrane; Cytoplasmic vesicle membrane; Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasm
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Expression
Tissue_Specificity: Expressed in T-cells (at protein level). -
Isoforms & Post-Translational Modification
IFNGR2 has an amino acid length of 337, molecular weight is 37806 Da.
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Subunit
Heterodimer with IFNGR1, to form the IFNG receptor complex.
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SwissProt ID
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Synonyms
AF-1; IFGR2; IFNGT1; IMD28
Documentation
References
[1]. Sakatsume M, et al. The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. J Biol Chem. 1995 Jul 21;270(29):17528-34. [Content Brief]
[2]. Kotenko SV, et al. Interaction between the components of the interferon gamma receptor complex. J Biol Chem. 1995 Sep 8;270(36):20915-21. [Content Brief]
[3]. Soh J, et al. Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell. 1994 Mar 11;76(5):793-802. [Content Brief]
[4]. Rosenzweig SD, et al. Characterization of a dipeptide motif regulating IFN-gamma receptor 2 plasma membrane accumulation and IFN-gamma responsiveness. J Immunol. 2004 Sep 15;173(6):3991-9. [Content Brief]
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