IL-4 Antibody (YA6361)
(Synonyms: Interleukin-4; IL4; IL 4; B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_HUMAN; B-cell stimulatory factor 1; BSF-1.)IL-4 Antibody (YA6361) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue
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Reactivity :
Human
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
IL-4 Antibody (YA6361) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-4.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 14 kDa
A synthesized peptide derived from human IL 4 aa 71-120
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Interleukin-4 (IL-4) is a critical Th2 cytokine that regulates immune responses by promoting differentiation of naive CD4+ T cells into Th2 cells. Mechanistically, IL-4 activates the JAK-STAT6 signaling pathway, leading to transcriptional induction of genes involved in humoral immunity, including IgE class switching in B cells. In disease models, IL-4 contributes to the pathogenesis of allergic inflammation and asthma by inducing eosinophilia, mucus hyperproduction, and alternatively activated macrophages. Compared with related isoforms such as IL-13, IL-4 exhibits unique receptor engagement, preferentially signaling through IL-4Rα paired with the common gamma chain, which defines distinct cellular responses. IL-4 agonists and inhibitors have been applied in experimental research to modulate Th2-skewed immune responses, enabling the study of allergic airway inflammation and potential therapeutic interventions. Experimental blockade of IL-4 reduces IgE production and airway hyperreactivity, confirming its central role in type 2 immunity and providing a framework for targeted immunomodulation in preclinical models. Therefore, IL-4 serves as both a mechanistic marker and a modifiable factor in studies of cytokine-driven inflammation.
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Subcellular Localization
Secreted
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Isoforms & Post-Translational Modification
IL-4 has 2 isomers: P05112-1: 17492 Da (predicted); P05112-2: 15797 Da (predicted).
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Subunit
Interacts with IL4R. Interacts with IL13RA1
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SwissProt ID
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Synonyms
Interleukin-4; IL4; IL 4; B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_HUMAN; B-cell stimulatory factor 1; BSF-1.
Documentation
References
[1]. Nelms K, et al. The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol. 1999;17:701-38. [Content Brief]
[2]. LaPorte SL,et al. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell. 2008 Jan 25;132(2):259-72 [Content Brief]
[3]. Seyfizadeh N, et al. Interleukin-13 as an important cytokine: A review on its roles in some human diseases. Acta Microbiol Immunol Hung. 2015 Dec;62(4):341-78. [Content Brief]
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