IP3 receptor Antibody (YA7280)
IP3 receptor Antibody (YA7280) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IP3 receptor.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, IHC-F, IF-Tissue, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:100-500 | 1:100-500 | 1:100-500 | 1:20-50 |
Product Details
IP3 receptor Antibody (YA7280) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IP3 receptor.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 314 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 314 kDa
A synthesized peptide derived from human ITPR1
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IP3 receptor is an Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix. Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations[1][2].
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Subcellular Localization
Endoplasmic reticulum membrane,Cytoplasmic vesicle, secretory vesicle membrane,Cytoplasm, perinuclear region
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Expression
Tissue_Specificity: Widely expressed -
Isoforms & Post-Translational Modification
Q14643 has 8 isomers: Q14643-1: 313929 Da (predicted); Q14643-2: 312163 Da (predicted); Q14643-3: 308539 Da (predicted); Q14643-4: 306773 Da (predicted); Q14643-5: 311135 Da (predicted); Q14643-6: 312003 Da (predicted); Q14643-7: 310237 Da (predicted); Q14643-8: 309209 Da (predicted).
Polyubiquitinated (By similarity)丨Phosphorylated by cAMP kinase (PKA) enhances calcium release (By similarity)丨Phosphorylated on tyrosine residues丨Palmitoylated by ZDHHC6 in immune cells, leading to regulation of ITPR1 stability and function -
Subunit
Homotetramer (By similarity)
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SwissProt ID
Documentation
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