kappa Opioid Receptor Antibody (YA3132)
(Synonyms: KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1)kappa Opioid Receptor Antibody (YA3132) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to kappa Opioid Receptor.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IP
-
Reactivity :
Rat
-
Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IP
IP: Immunoprecipitation
|
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
kappa Opioid Receptor Antibody (YA3132) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to kappa Opioid Receptor.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityRat
-
Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 43 kDa
Entrez Gene: 29335 Rat
SwissProt: P34975 Rat
A synthetic peptide of mouse Kappa Opioid Receptor
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
kappa Opioid Receptor is a G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions
-
Subcellular Localization
Cell membrane; Multi-pass membrane protein
-
Expression
Tissue_specificity:Detected in brain (at protein level) . Brain (neocortex, hippocampus, amygdala, medial habenula, hypothalamus, locus ceruleus, and parabrachial nucleus) -
Subunit
Interacts with NHERF1. Interacts with GABARAPL1 (By similarity)
-
SwissProt ID
-
Synonyms
KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
-
Research Field
Neuroscience
Documentation
Powered by Bioz
