L3MBTL3 Antibody (YA8183)(PBS only)

Cat. No.: HY-P88499A: Data Sheet User Guide for Antibodies
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L3MBTL3 Antibody (YA8183) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to L3MBTL3.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

L3MBTL3 Antibody (YA8183) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to L3MBTL3.

Host

Mouse

Molecular Weight

Predicted band size: 85.6 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q96JM7

Immunogen

Human recombinant protein fragment corresponding to amino acids 98-319 of human L3MBTL3 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:800-1500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity)

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：Q96JM7 has two isomers: Q96JM7-1: 88337 Da (predicted); Q96JM7-2: 85757 Da (predicted).

Subunit：Interacts with RNF2 (By similarity)

Synonyms

MBT-1; MBT1

Documentation

User Guide for Antibodies (1077 KB)