LRRK1 Antibody (YA7020)
(Synonyms: KIAA1790 antibody; Leucine rich repeat serine/threonine protein kinase 1 antibody; Leucine-rich repeat serine/threonine-protein kinase 1 antibody; LRRK 1 antibody; Lrrk1 antibody; LRRK1_HUMAN antibody; RIPK6 antibody; Roco1 antibody)LRRK1 Antibody (YA7020) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LRRK1.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500 | 1:50-1:100 |
Product Details
LRRK1 Antibody (YA7020) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LRRK1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 225kDa, additional band 60kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 225kDa, additional band 60kDa
Recombinant protein within mouse LRRK1 aa 1-164 / 2,015.
Endogenous
Immunogen affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LRRK1 is a Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A; this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts[1][2].
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Subcellular Localization
Cytoplasm,Cell membrane
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Expression
Tissue_Specificity: Expressed in osteoclasts and bone marrow stromal cells -
Isoforms & Post-Translational Modification
Q3UHC2 has three isomers: Q3UHC2-1: 225470 Da (predicted); Q3UHC2-2: 44456 Da (predicted); Q3UHC2-3: 129636 Da (predicted).
Autophosphorylated (By similarity) -
Subunit
Homodimer (By similarity)
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SwissProt ID
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Synonyms
KIAA1790 antibody; Leucine rich repeat serine/threonine protein kinase 1 antibody; Leucine-rich repeat serine/threonine-protein kinase 1 antibody; LRRK 1 antibody; Lrrk1 antibody; LRRK1_HUMAN antibody; RIPK6 antibody; Roco1 antibody
Documentation
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