MED15 Antibody (YA8649)
(Synonyms: ARC105; CAG7A; CTG7A; PCQAP; TIG-1; TIG1; TNRC7)MED15 Antibody (YA8649) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MED15.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
MED15 Antibody (YA8649) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MED15.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 82.4 kDa
Human recombinant protein fragment corresponding to amino acids 393-679 of human MED15 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MED15 component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway
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Subcellular Localization
Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney
Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA) -
Isoforms & Post-Translational Modification
Q96RN5 has three isomers: Q96RN5-1: 86753 Da (predicted); Q96RN5-2: 82581 Da (predicted); Q96RN5-3: 75927 Da (predicted).
Ubiquitinated by TRIM11, leading to proteasomal degradation -
Subunit
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11
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SwissProt ID
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Synonyms
ARC105; CAG7A; CTG7A; PCQAP; TIG-1; TIG1; TNRC7
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