MEF2D Antibody (YA7777)(PBS only)

製品番号: HY-P88093A: データシート User Guide for Antibodies
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MEF2D Antibody (YA7777) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEF2D.

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容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

MEF2D Antibody (YA7777) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEF2D.

Host

Mouse

分子量

Predicted band size: 55.8 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q14814

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-282 of human MEF2D produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

純度	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：Q14814 has 6 isomers: Q14814-1: 55938 Da (predicted); Q14814-2: 56091 Da (predicted); Q14814-3: 50680 Da (predicted); Q14814-4: 55114 Da (predicted); Q14814-5: 55267 Da (predicted); Q14814-6: 49856 Da (predicted).
Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity丨Acetylated on Lys-439 by CREBBP丨Sumoylated on Lys-439 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity丨Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity

Subunit：Interacts with MYOG (By similarity)

Synonyms

DKFZp686I1536

ドキュメンテーション

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/llc-mk2-cell.html [Content Brief]