MEF2D Antibody (YA7777)

Cat. No.: HY-P88093: Data Sheet User Guide for Antibodies
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MEF2D Antibody (YA7777) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEF2D.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

MEF2D Antibody (YA7777) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEF2D.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 55.8 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q14814

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-282 of human MEF2D produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：Q14814 has 6 isomers: Q14814-1: 55938 Da (predicted); Q14814-2: 56091 Da (predicted); Q14814-3: 50680 Da (predicted); Q14814-4: 55114 Da (predicted); Q14814-5: 55267 Da (predicted); Q14814-6: 49856 Da (predicted).
Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity丨Acetylated on Lys-439 by CREBBP丨Sumoylated on Lys-439 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity丨Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity

Subunit：Interacts with MYOG (By similarity)

Synonyms

DKFZp686I1536

Documentation

User Guide for Antibodies (1077 KB)