MEF2D Antibody (YA7777)
(Synonyms: DKFZp686I1536)MEF2D Antibody (YA7777) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEF2D.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-4000 | 1:150-500 |
Product Details
MEF2D Antibody (YA7777) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEF2D.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 55.8 kDa
Human recombinant protein fragment corresponding to amino acids 1-282 of human MEF2D produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MEF2D transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
Q14814 has 6 isomers: Q14814-1: 55938 Da (predicted); Q14814-2: 56091 Da (predicted); Q14814-3: 50680 Da (predicted); Q14814-4: 55114 Da (predicted); Q14814-5: 55267 Da (predicted); Q14814-6: 49856 Da (predicted).
Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity丨Acetylated on Lys-439 by CREBBP丨Sumoylated on Lys-439 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity丨Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity -
Subunit
Interacts with MYOG (By similarity)
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SwissProt ID
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Synonyms
DKFZp686I1536
Documentation
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