2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. MKL1 Antibody (YA7889)

MKL1 Antibody (YA7889) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MKL1.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量 価格（税別） 在庫状況
20 μL $115 見積もりとリードタイムを求めるのご確認
50 μL $185 見積もりとリードタイムを求めるのご確認
100 μL $300 見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

MKL1 Antibody (YA7889) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MKL1.
Host

Mouse
Clonality

Monoclonal
Species Reactivity
Human
SwissProt ID
Immunogen

Human recombinant protein fragment corresponding to amino acids 165-397 of human MKL1 produced in E.coli.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:150-500
Sensitivity Endogenous 純度 Affinity purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG1  
Appearance

Liquid
Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus
Subcellular Localization：Cytoplasm,Nucleus
Expression：
Tissue_Specificity: Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain (PubMed:11344311). Expressed in peripheral blood mononuclear cells (at protein level) (PubMed:26224645)
Isoforms & Post-Translational Modification：Q969V6: 931 amino acids, molecular weight 98919 Da.
Subunit：Interacts with SRF, forming the SRF-MRTFA nuclear complex which binds the 5'-CArG-3' consensus motif (CArG box) on DNA via SRF (PubMed:14565952, PubMed:19350017)
Synonyms
BSAC; MAL; MRTF-A
ドキュメンテーション
User Guide for Antibodies (1077 KB)

MKL1 Antibody (YA7889) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
MKL1 Antibody (YA7889)
製品番号:
HY-P88205
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