2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Mucolipin-1 Antibody (YA6667)

Mucolipin-1 Antibody (YA6667)

製品番号: HY-P86974
User Guide for Antibodies Technical Support

Mucolipin-1 Antibody (YA6667) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mucolipin-1.

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容量 価格（税別） 在庫状況 数量
20 μL $162 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL $240 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL $384 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   お問い合わせ  
Synthetic products have potential research and development risk.
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* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Mucolipin-1 Antibody (YA6667) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mucolipin-1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
分子量
Predicted band size: 65 kDa;
Observed band size: 35-40 kDa (PMID: 16257972)
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Recombinant protein within human Mucolipin-1 aa 66-321.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:1000
純度 affinity purified. Conjugation Non-conjugated
Modification Unmodified Isotype IgG
Appearance

Liquid
Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:18794901, PubMed:25720963, PubMed:27623384, PubMed:29019983). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:25720963, PubMed:29019983). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:25720963, PubMed:27623384, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity)|May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase
Subcellular Localization：Late endosome membrane,Lysosome membrane,Cytoplasmic vesicle membrane,Cell projection, phagocytic cup,Cytoplasmic vesicle, phagosome membrane,Cell membrane
Expression：
Tissue_Specificity: Widely expressed in adult and fetal tissues
Subunit：Homotetramer (PubMed:28112729, PubMed:29019983)
Synonyms
MCLN1_HUMAN antibody; Mcoln 1 antibody; Mcoln1 antibody; MG 2 antibody; MG-2 antibody; MG2 antibody; ML 4 antibody; ML4 antibody; MLIV antibody; MST080 antibody; MCLN1_HUMAN antibody; Mcoln 1 antibody; Mcoln1 antibody; MG 2 antibody; MG-2 antibody; MG2 antibody; ML 4 antibody; ML4 antibody; MLIV antibody; MST080 antibody; MSTP080 antibody; Mucolipidin antibody; Mucolipin 1 antibody; Mucolipin-1 antibody; Mucolipin1 antibody; TRP ML1 antibody; TRPML1 antibody;
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Mucolipin-1 Antibody (YA6667) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Mucolipin-1 Antibody (YA6667)
製品番号:
HY-P86974
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