Mucolipin-1 Antibody (YA6667)

Cat. No.: HY-P86974: Data Sheet User Guide for Antibodies
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Mucolipin-1 Antibody (YA6667) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mucolipin-1.

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사이즈	재고	수량
20 μL	견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	견적 받기

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

Mucolipin-1 Antibody (YA6667) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mucolipin-1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

분자량

Predicted band size: 65 kDa;

Observed band size: 35-40 kDa (PMID: 16257972)

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9GZU1

Gene ID

57192 [NCBI]

Immunogen

Recombinant protein within human Mucolipin-1 aa 66-321.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:1000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:18794901, PubMed:25720963, PubMed:27623384, PubMed:29019983). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:25720963, PubMed:29019983). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:25720963, PubMed:27623384, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity)|May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase

Subcellular Localization：Late endosome membrane,Lysosome membrane,Cytoplasmic vesicle membrane,Cell projection, phagocytic cup,Cytoplasmic vesicle, phagosome membrane,Cell membrane

Expression：
Tissue_Specificity: Widely expressed in adult and fetal tissues

Subunit：Homotetramer (PubMed:28112729, PubMed:29019983)

Synonyms

MCLN1_HUMAN antibody; Mcoln 1 antibody; Mcoln1 antibody; MG 2 antibody; MG-2 antibody; MG2 antibody; ML 4 antibody; ML4 antibody; MLIV antibody; MST080 antibody; MCLN1_HUMAN antibody; Mcoln 1 antibody; Mcoln1 antibody; MG 2 antibody; MG-2 antibody; MG2 antibody; ML 4 antibody; ML4 antibody; MLIV antibody; MST080 antibody; MSTP080 antibody; Mucolipidin antibody; Mucolipin 1 antibody; Mucolipin-1 antibody; Mucolipin1 antibody; TRP ML1 antibody; TRPML1 antibody;

각종 서류

User Guide for Antibodies (1077 KB)