NeuroD2 Antibody (YA2369)
(Synonyms: bHLHa1; NDR2; NDRF; neuroD related factor; NeuroD2; neurogenic differentiation 2)NeuroD2 Antibody (YA2369) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NeuroD2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
NeuroD2 Antibody (YA2369) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NeuroD2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
Entrez Gene: 4761 Human ; 18013 Mouse ; 54276 Rat
SwissProt: Q15784 Human ; Q62414 Mouse ; Q63689 Rat
OMIM: 618374 Human
A synthesized peptide derived from human NeuroD2 aa300-382.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NeuroD2 transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter
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Subcellular Localization
Nucleus
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Subunit
Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20.
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SwissProt ID
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Synonyms
bHLHa1; NDR2; NDRF; neuroD related factor; NeuroD2; neurogenic differentiation 2
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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