NeuroD2 Antibody (YA9737)
(Synonyms: bHLHa1, class A basic helix loop helix protein 1, Class A basic helix-loop-helix protein 1, NDF2_HUMAN, NDR2, NDRF, neuroD related factor, NeuroD-related factor, NeuroD2, neurogenic basic helix loop helix protein)NeuroD2 Antibody (YA9737) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to NeuroD2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Rat, Mouse
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500 | 1:200-1000 |
Product Details
NeuroD2 Antibody (YA9737) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to NeuroD2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Rat, Mouse
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Calculated Molecular Weight Predicted band size: 41 kDa;
Recombinant protein of Human NeuroD2 (aa 260-382).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NeuroD2 is a Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity)
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
NeuroD2 has an amino acid length of 382, molecular weight is 41361 Da.
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Subunit
Interacts with TCF3, TCF4 and TCF12.
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SwissProt ID
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Synonyms
bHLHa1, class A basic helix loop helix protein 1, Class A basic helix-loop-helix protein 1, NDF2_HUMAN, NDR2, NDRF, neuroD related factor, NeuroD-related factor, NeuroD2, neurogenic basic helix loop helix protein
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