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NR1I3 Antibody (YA7835)(PBS only)

(Synonyms: CAR; CAR1; MB67)

NR1I3 Antibody (YA7835) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NR1I3.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • NR1I3 Antibody (YA7835)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:100-500

Product Details

Description

NR1I3 Antibody (YA7835) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NR1I3.

  • Host Mouse
  • Species Reactivity
    Human
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-236 of human NR1I3 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NR1I3 binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element

  • Subcellular Localization

    Nucleus,Cytoplasm,Cytoplasm, cytoskeleton

  • Expression


    Tissue_Specificity: Predominantly expressed in liver
    Induction: By dexamethasone

  • Isoforms & Post-Translational Modification

    Q14994 has 15 isomers: Q14994-1: 39942 Da (predicted); Q14994-2: 39558 Da (predicted); Q14994-3: 35588 Da (predicted); Q14994-4: 31900 Da (predicted); Q14994-5: 36416 Da (predicted); Q14994-6: 36961 Da (predicted); Q14994-7: 35043 Da (predicted); Q14994-8: 40488 Da (predicted); Q14994-9: 34778 Da (predicted); Q14994-10: 35323 Da (predicted); Q14994-11: 35708 Da (predicted). Q14994-12: 38304 Da (predicted); Q14994-13: 38466 Da (predicted); Q14994-15: 33405 Da (predicted); Q14994-16: 30262 Da (predicted).
    Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation

  • Subunit

    Interacts with ECT2 (By similarity)

  • SwissProt ID

    Q14994

  • Synonyms

    CAR; CAR1; MB67

NR1I3 Antibody (YA7835)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • NR1I3 Antibody (YA7835)(PBS only) Product Image