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Pannexin 1 Antibody (YA2649)

(Synonyms: innexin; MRS1; Pannexin 1; Panx1; PX1)
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Pannexin 1 Antibody (YA2649) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pannexin 1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IP

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS containing 50% glycerol, and 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
  • Pannexin 1 Antibody (YA2649) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:50

Product Details

Description

Pannexin 1 Antibody (YA2649) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pannexin 1.

  • Host Rabbit
  • Clonality Recombinant, Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 48 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 48 kDa
Species Reactivity Database

Entrez Gene: 24145 Human

SwissProt: Q96RD7 Human

Immunogen

A synthesized peptide derived from human Pannexin 1 aa360-426/426.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3104996

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS containing 50% glycerol, and 0.02% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Pannexin 1 is an Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis. Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate. Can release ATP upon activation tH2O2gh phosphorylation or cleavage at C-terminus. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; During apoptosis, the C terminal tail is cleaved by caspases, whicH2O2ens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells[1][2][3][4][5][6].

  • Subcellular Localization

    Cell membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane; Multi-pass membrane protein

  • Expression


    Tissue_specificity:Widely expressed (PubMed:30918116) . Highest expression is observed in oocytes and brain (PubMed:30918116) . Detected at very low levels in sperm cells (PubMed:30918116)

  • Isoforms & Post-Translational Modification

    Q96RD7 has 2 isomers: Q96RD7-1: 48050 Da (predicted); Q96RD7-2: 47635 Da (predicted).
    S-nitrosylation inhibits channel currents and ATP release;N-glycosylation plays a role in cell surface targeting. Glycosylation at its extracellular surface makes unlikely that two oligomers could dock to form an intercellular channel such as in gap junctions (PubMed:17715132, PubMed:32494015, PubMed:33947837). Exists in three glycosylation states: non-glycosylated (GLY0), high-mannose glycosylated (GLY1), and fully mature glycosylated (GLY2) (PubMed:30918116);Cleaved by CASP3 and CASP7 during apoptosis. Cleavage opens the channel for the release of metabolites and induces plasma membrane permeability during apoptosis;Phosphorylated at Tyr-199 by SRC. Phosphorylation activates ATP release. Constitutively phosphorylated in vascular smooth muscle cells

  • Subunit

    Homoheptameric

  • SwissProt ID

    Q96RD7

  • Gene ID
    24145 [NCBI]
  • Synonyms

    innexin; MRS1; Pannexin 1; Panx1; PX1

  • Research Field

    Neuroscience

Pannexin 1 Antibody (YA2649) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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