PARN Antibody (YA7807)(PBS only)

製品番号: HY-P88123A: データシート User Guide for Antibodies
FAQs
Technical Support

PARN Antibody (YA7807) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PARN.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

PARN Antibody (YA7807) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PARN.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O95453

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-266 of human PARN produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-200

純度	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417)

Subcellular Localization：Nucleus,Cytoplasm,Nucleus, nucleolus

Expression：
Tissue_Specificity: Ubiquitous

Isoforms & Post-Translational Modification：O95453 has four isomers: O95453-1: 73451 Da (predicted); O95453-2: 66574 Da (predicted); O95453-3: 67722 Da (predicted); O95453-4: 52989 Da (predicted).
Phosphorylation by MAPKAPK2, preventing GADD45A mRNA degradation after genotoxic stress

Subunit：Homodimer (PubMed:10801819, PubMed:16281054)

Synonyms

DAN

ドキュメンテーション

User Guide for Antibodies (1077 KB)

PARN Antibody (YA7807)(PBS only) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PARN Antibody (YA7807)(PBS only)

Product Detail

Background

説明

PARN Antibody (YA7807)(PBS only) 関連分類

最近チェックした製品:

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