PDCL3 Antibody (YA8782)(PBS only)

Cat. No.: HY-P89098A: Data Sheet User Guide for Antibodies
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PDCL3 Antibody (YA8782) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDCL3.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

PDCL3 Antibody (YA8782) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDCL3.

Host

Mouse

Molecular Weight

Predicted band size: 27.4 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9H2J4

Immunogen

Full length human recombinant protein of human PDCL3 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430)

Subcellular Localization：Cytoplasm,Cytoplasm, perinuclear region,Endoplasmic reticulum

Expression：
Tissue_Specificity: Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430)

Isoforms & Post-Translational Modification：Q9H2J4: 239 amino acids, molecular weight 27614 Da.

Subunit：Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) (PubMed:23792958, PubMed:26059764)

Synonyms

HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1

Documentation

User Guide for Antibodies (1077 KB)